An alpha-glucosidase inhibitor can help control blood glucose levels in a patient with diabetes mellitus. These drugs should not be used if certain conditions are present.
alpha-Glucosidase inhibitors include:
(1) acarbose (Precose)
(2) miglitol (Glyset)
Mechanism of action: decreased rate of absorption of carbohydrates from the gastrointestinal tract following meals
Contraindications to their use:
(1) renal failure
(2) liver disease (hepatic cirrhosis, hepatitis, etc)
(3) inflammatory bowel disease (Crohn's disease, ulcerative colitis)
(4) ulceration in the small or large intestine
(5) intestinal obstruction
(6) diabetic ketoacidosis
(7) hypersensitivity to alpha-glucosidase inhibitors
(8) irritable bowel disease
Problems that may arise from the use of these agents:
(1) excessive gas (as luminal bacteria digest the carbohydrates)
(3) bloating and abdominal discomfort
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Purpose: To identify contraindications to the use of an alpha-glucosidase inhibitor in a patient with diabetes mellitus.
Specialty: Endocrinology, Clinical Laboratory
Objective: risk factors, prevention
ICD-10: T38.3, E14.8, E14.9,