Crohn's disease is described as a multigenic disorder. The presence of certain alleles may increase the risk that a patient will develop Crohn's disease.
Criteria for Risk (Weersma et al)
autophagy-related 16-like 1
Drosophila discs large homologue 5
inflammatory bowel disease 5
interleukin 23 receptor
homozygous for rs11209026*G
nucleoside-binding and oligomerisation domain 2
polymorphisms in one or more of: R702W, G908R, 3020insC
• IBD5 includes SLC22A4 and SLC22A5 (solute carrier family 22 members 4 and 5)
number of alleles =
= (presence of 1 or more NOD1 risk alleles) + (number of ATG16L1 alleles) + (number of DLG5 alleles) + (number of IBD5 alleles) + (homozygous for IL23R)
Number of Alleles Present
Odds Ratio for Crohn's Disease
0 or 1
8 or 9
• According to the text on page 393 of Weersma et al the maximum number of risk alleles is 9, but my maximum count is 8. One way to a higher number is to count the number of alleles in IL23R.
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