Vang and Shih reported an algorithm for evaluating serous tubal abnormalities of the fallopian tube. This can help to properly classify this challenging problem. The authors are from the Johns Hopkins University.
Parameters:
(1) morphology
(2) p53
(3) Ki-67
STIC = serous tubal intra-epithelial carcinoma
STIL = serous tubal intra-epithelial lesion
p53 signature = precursor to STIC, with >= 12 consecutive secretory cells showing strong stianng for p53
Morphology
p53
Ki-67
Diagnosis
unequivocal STIC
aberrant
high >= 10%
STIC
aberrant
low< 10%
STIL
wild type
high >= 10%
STIL
wild type
low< 10%
STIL
suspicious STIC
aberrant
high >= 10%
STIC
aberrant
low< 10%
STIL
wild type
high >= 10%
STIL
wild type
low< 10%
normal/reactive
not suspicious
aberrant
high >= 10%
STIL
aberrant
low< 10%
p53 signature
wild type
high >= 10%
normal/reactive
wild type
low< 10%
normal/reactive
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