Shirey et al used an algorithm for selecting blood products for transfusing a patient with a warm autoantibody. This is intended to reduce the risk of a delayed transfusion reaction to a masked alloantibody. The authors are from the Johns Hopkins University in Baltimore.


Donor blood selected for transfusion should be:

(1) matched for the patient's ABO and D type

(2) negative for known alloantibodies

(3) negative for alloantibodies detected after allogeneic adsorption (this step is not necessary if the patient's complete phenotype is known)

(4) matched for other important antigens (see below)


There are 3 options for matching other antigens:

(1) match the complete phenotype of the patient

(2) match as much of the phenotype of the patient as is known

(3) at a minimum be E and K antigen negative


Complete phenotype:

(1) C, E, c, and e

(2) K

(3) Jka and Jkb

(4) Fya and Fyb

(5) S and s


Leukopoor blood should be transfused to reduce the risk of a febrile reaction that might be mistaken for a hemolytic transfusion reaction.


To read more or access our algorithms and calculators, please log in or register.