Pereira et al reported an algorithm for the differential diagnosis of crystalline retinopathy. This was a decision tree based on clinical and ophthalmologic findings. The authors are from Providence VA Medical Center and the New England College of Optometry.
Laterality
History
Crystal Deposits
Condition
unilateral
inner retina
retinal detachment
within peripheral arterioles, refractile
cholesterol embolus
bilateral
IV drug use
within retinal arterioles
talc retinopathy
history of breast cancer
inner retina
tamoxifen retinopathy
canthaxanthin therapy
inner retina
canthaxanthin retinopathy
history of psychosis
flupentixol retinopathy
renal failure
outer retina
methoxyflurane exposure; primary oxalosis
renal failure
scintillating retinal pigment with mottling of retinal pigment epithelium
nephropathic calcinosis
spastic diplegia
perifoveal inner retina
Sjorgren-Larsson syndrome; Kjellin syndrome
negative
all retinal layers and cornea
Bietti's dystrophy
negative
macular atrophy, right angled venules; juxta-uveal telangiectasia
macular telangiectasia type 2
negative
macular atrophy, mottling of retinal pigment epithelium, hyper-reflective Drusen
age-related macular degeneration
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