Nabhan et al proposed an algorithm for managing a patient with chronic lymphocytic leukemia (CLL). The authors are from the University of Chicago.
Patient selection: chronic lymphocytic leukemia
Parameters:
(1) primary mutation
(2) secondary mutation
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Primary Mutation
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Secondary Mutation
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Management
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17p deletion or TP53 mutation
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clinical trial - early therapy or BCR pathway or anti-BCL2 or HSCT
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11q deletion
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BIRC3
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clinical trial; possibly target NFkB
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SF3B1
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clinical trial
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other
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randomized trial comparing newer therapies with standard care
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none of the above
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NOTCH1 mutation
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clinical trial of non-anti-CD20 based therapy or therapy to increase CD20 expression
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other
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randomized trial comparing newer therapies with standard care
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