Alexander’s disease can be classified based on the age of onset. Some patients present during childhood.

Age at onset: childhood or early adolescence


Death: early adulthood


Clinical features:

(1) bulbar or pseudobulbar findings (speech abnormalities, swallowing difficulties, vomiting)

(2) spasticity in lower extremities

(3) ataxia

(4) poor motor coordination (clumsiness)

(5) gradual loss of intellectual function

(6) seizures

(7) megalencephaly

(8) breathing difficulty

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