Xiong et al used the albumin to alkaline phosphatase ratio as a prognostic index in patients with cholangiocarcinoma. The authors ae from Peking Union Medical College in Beijing.
Patient selection: cholangiocarcinoma
Outcome: post-operative overall survival
Parameters:
(1) serum albumin in g/L
(2) serum alkaline phosphatase in ng/mL
albumin to alkaline phosphatase ratio =
= (serum albumin) / (serum alkaline phosphatase)
Interpretation:
• minimum ratio: less than 0.01
• maximum ratio: around 1
• A ratio < 0.41 was associated with a worse long-term survival.
Additional predictors of poor survival:
(1) large tumor size (>= 5 cm)
(2) multiple tumors (>= 2)
(3) clinical stage III or IV
(4) noncurative resection
|
Overall Survival
|
Ratio >= 0.41
|
Ratio < 0.41
|
|
1-year
|
82%
|
70%
|
|
3-year
|
54%
|
38%
|
|
5-year
|
33%
|
17%
|
Limitations:
• Serum alkaline phosphatase values will vary with the analytical method.
Performance:
• The sensitivity was 0.74 and specificity 0.83.
