Reported effects include: paranoia, panic or a psychedelic experience
Theories for adverse effects associated with edibles:
(1) greater potency of marijuana products compared to the past
(2) taking too high of an oral dose
(3) presence of higher concentrations of psychoactive metabolites such as 11-hydroxy-THC
(4) pre-existing psychiatric issues
(5) polypharmacy
(6) novice user without tolerance
The consumed dose of an edible marijuana product may be difficult to gauge. A delay in onset may cause the patient to take an additional dose. In addition, absorption tends to be prolonged which influences the duration of effect.
Ingested marijuana goes through the liver where it undergoes first-pass metabolism. This results in release of metabolites, some of which are more psychoactive. The blood concentration of 11-hydroxy-THC is considerably increased following ingestion compared to smoking.
An important issue is accidental ingestion of an edible marijuana product, especially in children. The unexpected intoxication may catch the person off guard and cause a panic reaction.
