Problems in infants that have been linked to maternal medications may include:
(1) sedation or agitation
(2) insomnia
(3) diarrhea
(4) vomiting
(5) skin rash
(6) apnea
(7) bradycardia or tachycardia
plus many others
Risk factors for an adverse drug reaction in a pediatric patient:
(1) high dose of the drug
(2) feeding associated with peak drug levels
(3) neonate, especially if small
(4) impaired drug excretion (renal impairment, drug interaction)
(5) exclusive breastfeeding
The diagnosis is made by:
(1) detecting an unexplained problem in the child
(2) reviewing the mother's medications
(3) reversal of the reaction on discontinuation of the medication or breastfeeding
