Adverse Drug Reaction Classification | Medical Algorithm

McDonnell and Jacobs classified adverse drug reactions (ADRs) based on their severity. The authors are from Temple University in Philadelphia.

Parameters:

(1) duration of symptoms or injury

(2) impact on hospital stay

(3) specific therapy required

(4) life-threatening or fatal

Parameter	Severe (any of the following)	Moderate	Minor (all of the following)
duration	permanent	>= 24 hours	< 24 hours
impact on hospital stay	requires intensive care (admission to the ICU)	prolongs hospital stay by > 24 hours; requires hospital admission but not to ICU	does not prolong hospital stay (or does not require admission)
specific therapy or antidote required	NA	yes	no
life-threatening or fatal	yes	no	no

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Classification for Severity of Adverse Drug Reaction