Laboratory triggers may include:
(1) INR > 5 (or 6)
(2) aPTT > 100 seconds
(3) high or rising serum creatinine (> 2 times above baseline)
(4) serum glucose < 50 or > 150 mg/dL
(5) hyperkalemia or hypokalemia
(6) hyponatremia
(7) peak serum drug level toxic
(8) trough serum drug level above target or subtherapeutic
(9) low serum albumin (< 3 g/dL)
(10) leucopenia (WBC count < 3,000 per µL)
(11) thrombocytopenia (platelet count < 50,000 per µL)
(12) abrupt drop in hemoglobin > 25%
(13) positive D-dimer
(14) positive Clostridium difficile toxin test
(15) elevated liver function tests (AST and/or ALT)
