A pediatric patient with an adrenocortical tumor may experience a combination of Cushing's disease, precocious puberty and/or virilization.


Clinical features related to the tumor itself:

(1) palpable abdominal mass


Clinical features related to excess glucocorticoids:

(1) buffalo hump

(2) moon face

(3) centripetal fat distribution

(4) hypertension

(5) weight gain


Clinical features of androgenic steroids:

(1) pubic hair

(2) clitoral or penile hypertrophy

(3) acne

(4) deep voice

(5) facial hair

(6) hirsutism

(7) accelerated growth velocity


To read more or access our algorithms and calculators, please log in or register.