Administration of Rh Immune Globulin (RhoGAM, RhIG) to Prevent Alloimmunization After Administering Platelets from an Rh-Positive Donor to an Rh-Negative Patient

 

NOTE: Rh antigen is not present on platelets, and survival of platelets from an Rh-positive donor is normal in a patient with anti-D.

Product	Amount of Packed RBC
random concentrate	0.5 mL per unit (2 mL in pool of 4 units to 4 mL in pool of 8 units)
pheresis product	2 mL

 

1 unit of RhoGAM is immunoprophylactic for up to 15 mL of Rh-positive packed RBCs:

(1) for up to 30 random concentrates

(2) for up to 7 platelet pheresis products

 

NOTE: Micro-RhoGAM can be given for up to 2.5 mL of Rh-positive red blood cells, However, I am not sure that there is a significant cost savings, while it is unlikely that a patient requiring platelet transfusions that badly would require only 1 pheresis product or 5 random concentrates.

 

If hematoma development at the site of intramuscular injection is a concern, an intravenous injectable form is available.