Granulocyte Colony Stimulating Factor (G-CSF) should be given to pediatric patients with neutropenia if certain indications are present.
Patient selection: pediatric patient with neutropenia
Indications for long-term therapy (daily or intermittent) - any of the following:
(1) severe congenital neutropenia (SCN)
(2) cyclic neutropenia
(3) Glycogen storage disease 1b or certain other pathologic conditions
(4) autoimmune neutropenia associated with severe or recurrent bacterial or fungal infections
(5) idiopathic neutropenia associated with severe or recurrent bacterial or fungal infections
Indications for on-demand therapy:
(1) prophylaxis associated with a surgical procedure
(2) both of the following:
(2a) one of the following: autoimmune, idiopathic or neutropenia associated with other pathologic condition not receiving long-term therapy
(2b) one of the following: isolated or prolonged fever OR fever associated with severe infection OR rapid deterioration in clinical condition OR sepsis
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Specialty: Infectious Diseases, Pharmacology, clinical, Pedatrics