Oxipurinol is a major metabolite of allopurinol and is excreted by the kidneys. The dose of allopurinol needs to be adjusted for changes in renal function.
If the person is receiving routine hemodialysis (sessions 2 to 3 times per week) then the allopurinol dose is 300 mg soon after each dialysis session. If other forms or schedules of dialysis are given then it may be necessary to consult with a hospital pharmacists on the optimum dosage schedule.
Estimated Creatinine Clearance in ml/min
Dose of Allopurinol
140
400 mg per day
120
350 mg per day
100
300 mg per day
80
250 mg per day
60
200 mg per day
40
150 mg/day
20
100 mg per day
10
100 mg every 2 days
0
100 mg every 3 days
dose in mg per day for creatinine clearance from 20 to 140 mL/min =
= (2.5 * (creatinine clearance)) + 50
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