Several factors affect the adequacy of a bone marrow biopsy in a pediatric patient.
A bone marrow is adequate if:
(1) diagnoses can be made
(2) all relevant testing can be completed
An inadequate bone marrow biopsy may:
(1) be crushed or otherwise too distorted to interpret
(2) contain excessive cortical bone
(3) miss a target lesion
(4) consist mostly of blood
(5) not contain a representative sampling of hematopoietic tissue
The recommended length for a biopsy core should be >= 1 cm in length.
A core < 0.5 cm has a high rate of inadequacy.
Since a core may break during handling, total length needs to be considered as well.
A blood clot in the shape of a core should not be counted.
Since the core shrinks during processing, the assessment should be based on the original length.
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Specialty: Hematology Oncology, Clinical Laboratory