Hypertrophy of the tonsils and adenoids can be a significant problem for children with sickle cell anemia.

Tonsillar and adenoidal hypertrophy can result in:

(1) airway obstruction

(2) obstructive sleep apnea

(3) recurrent infection (chronic tonsillitis)


Oxygen desaturation and recurrent infection can trigger pain or vaso-occlusive crises.


Resection of enlarged tonsils and adenoids can result in significant clinical improvement.

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