Adenosquamous carcinoma of the pancreas is an uncommon tumor that can have a poor prognosis.
Features of an adenosquamous carcinoma of the pancreas:
(1) The tumor tends to occur in males > 60 years of age.
(2) The tumor shows features of both adenocarciinoma and squamous cell carcinoma. The tumor will show areas of positive immunostaining for CK5/6 and p63.
(3) Central necrosis may be seen on imaging studies.
The tumors often show mutations in K-ras.
Poor prognostic factors:
(1) metastatic disease
(2) inability to completely resect at the time of initial surgery
(3) failure to treat aggressively
To read more or access our algorithms and calculators, please log in or register.
