A patient with a monoclonal gammopathy may develop acute systemic capillary leak syndrome (ASCLS).
Clinical features of acute capillary leak syndrome - episodes of:
(1) hypotensive shock
(2) anasarca
(3) hemoconcentration (elevated hemoglobin and hematocrit)
(4) hypoalbuminemia
(5) multiorgan dysfunction
Criteria for implicating monoclonal gammopathy as the cause:
(1) presence of a monoclonal gammopathy
(2) exclusion of other causes of the capillary leak syndrome
Some investigators have found that infusion of intravenous immunoglobulins (IVIg) is associated with rapid clinical improvement.
