Zika virus and other flaviviruses may affect the eyes.
Patient selection: Zika virus infection
The patient may present with reduced visual acuity. The patient may have other signs of a viral infection (fever, headache, rash, arthralgias).
Ophthalmologic manifestations may include:
(1) conjunctivitis
(2) maculopathy
(3) chorioretinitis, placoid or multifocal non-necrotizing
(4) uveitis
Risk factors for more severe disease:
(1) immunocompromised status
The workup for a patient with these findings should include:
(1) molecular tests for dengue, Zika, West Nile and other Flaviviruses based on exposure risk.
(2) imaging of fundus lesions (fluorescein and cyanine green angiography; wide-angle autofluorescence; optical coherence tomography)
