Yamamoto et al reported a severity score for evaluating patients with acute necrotizing encephalopathy (ANE). The authors are from Nagoya University, Juntendo University and the University of Tokyo.
Patient selection: acute necrotizing encephalopathy
Parameters:
(1) age in months
(2) shock at onset
(3) brainstem lesions
(4) platelet count
(5) CSF protein in mg/dL
|
Parameter |
Finding |
Points |
|
age in months |
<= 48 months |
0 |
|
|
> 48 months |
2 |
|
shock at onset |
no |
0 |
|
|
yes |
3 |
|
brainstem lesions |
no |
0 |
|
|
yes |
2 |
|
platelet count |
>= 100,000 per µL |
0 |
|
|
< 100,000 per µL |
1 |
|
CSF protein |
<= 60 mg/dL |
0 |
|
|
> 60 mg/dL |
1 |
severity score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 9
• The higher the score the greater the severity. Severe sequelae can occur with any severity score but deaths were most frequent in a high risk group.
|
Severity Score |
Risk Group |
|
0 or 1 |
low |
|
2, 3 or 4 |
medium |
|
>= 5 |
high |
Specialty: Neurology
