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Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) Prognostic Score

Purpose: To evaluate a patient with newly diagnosed, cytogenetically normal acute myeloid leukemia (CN-AML) using the score of Malagola et al.

Description

Malagola et al reported a simple prognostic score for newly diagnosed patients with cytogenetically normal acute myeloid leukemia (CN-AML). This can help to stratify a patient for subsequent management. The authors are from multiple hospitals in Italy and participants in GIMEMA (Gruppo Italiano Malattie EMatologiche dell’Adulto) LAM99p clinical trial.


 

Patient selection: AML with age <= 65 years of age AND cytogenetically normal

 

Parameters:

(1) age in years

(2) white blood cell count

(3) primary vs secondary AML

 

Parameter

Finding

Points

age in years

< 50 years

0

 

>= 50 (to 65) years

1

white blood cell count

< 20 * 10^9/L

0

 

>= 20 * 10^9/L

2

primary vs secondary AML

primary

0

 

secondary

2

 

prognostic index score = PIS =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the worse the prognosis.

 

Prognostic Index Score

Risk Group

5 Year Overall Survival

0 to 1

low

55%

2

intermediate

30%

3, 4 or 5

high

15%

 


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Specialty

Objective

ICD-10