Lurasidone is a second-generation atypical antipsychotic agent. A number of signs and symptoms may occur if an overdose occurs.
CYP3A4 inhibitors may increase serum levels.
Signs and symptoms that may be seen in an overdose:
(1) cardiac arrhythmia
(2) prolongation of QTc
(3) hypotension and circulatory arrest
(4) nausea
(5) hyperglycemia
Neurologic findings:
(1) somnolence to obtundation
(2) seizures
(3) dystonia and/or akathisia
(4) Parkinsonism
(5) cerebrovascular vascular event (transient ischemic event, stroke)
Complications may include:
(1) aspiration pneumonia
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Specialty: Toxicology, Emergency Medicine, Critical Care, Neurology
