Infusion of intravenous immune globulin (IVIG) may be followed by an acute infusion reaction.
Clinical features of the acute infusion reaction:
(1) headache
(2) fever
(3) chills
(4) myalgia
(5) nausea and vomiting
(6) hypotension
(7) backache
(8) flushing
The onset is usually within 1 hour of starting the infusion.
Symptoms using resolve within 30 minutes. The infusion often can be continued at a slower rate of infusion.
Risk factors:
(1) rapid infusion
(2) infusion of a large dose
(3) failure to respond to symptoms (reduce infusion rate or discontinue until symptoms subside)
Need to consider other acute reactions to IVIG:
(1) hemolysis
(2) renal failure
(3) aseptic meningitis
(4) acute lung injury
(5) anaphylaxis
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Specialty: Clinical Laboratory
ICD-10: ,
