Patient selection: acute HEV superimposed on chronic HBV
Patients presented with signs of acute hepatitis.
Severe outcomes (liver failure and/or decompensation): 49%
Short-term mortality: 13%
The most important risk factors for poor outcome was the presence of cirrhosis, even if well-compensated.
Additional risk factors for patients with cirrhosis:
(1) male sex
(2) alcohol use
(3) pre-existing renal disease
Risk factors for patients without cirrhosis:
(1) HBeAg-negative
(2) intermediate HBV DNA levels (500 to 5*10^5 IU/mL)
(3) alcohol consumption
(4) diabetes
(5) pre-existing renal disease
(6) failure to treat adequately with anti-HBV therapy
