Sidoroff et al reported a score for the diagnosis of Acute Generalized Exanthematous Pustulosis (AGEP). The authors are from multiple institutions in Europe and Israel.
Parameters:
(1) pustules
(2) erythema
(3) distribution/pattern
(4) postpustular desquamation
(5) mucosal involvement
(6) acute onset (<= 10 days)
(7) resolution in days
(8) body temperature in °C
(9) absolute neutrophil count per microliter
(10) evidence of another disease on histology
(11) other histologic features
|
Parameter |
Finding |
Points |
|
pustules |
typical |
2 |
|
|
compatible |
1 |
|
|
insufficient |
0 |
|
erythema |
typical |
2 |
|
|
compatible |
1 |
|
|
insufficient |
0 |
|
distribution/pattern |
typical |
2 |
|
|
compatible |
1 |
|
|
insufficient |
0 |
|
postpustular desquamation |
yes |
1 |
|
|
no |
0 |
|
|
insufficient |
0 |
|
mucosal involvement |
no |
0 |
|
|
yes |
-2 |
|
acute onset |
yes |
0 |
|
|
no |
-2 |
|
resolution |
<= 15 days |
0 |
|
|
> 15 days |
-4 |
|
body temperature |
< 38°C |
0 |
|
|
>= 38°C |
1 |
|
ANC |
< 7,000 per µL |
0 |
|
|
>= 7,000 per µL |
1 |
|
other disease |
no |
0 |
|
|
yes |
-10 |
|
other histology |
spongiform subcorneal and/or intraepidermal pustules with papillary edema |
3 |
|
|
|
2 |
|
|
exocystosis of neutrophils |
1 |
|
|
none of these |
0 |
(1) non-spongiform subcorneal and/or intraepidermal pustules
(2) NOS pustules with papillary edema
(3) (subcorneal and/or epidermal spongiform or NOS pustules) without papillary edema
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -18
• maximum score: 12
|
Score |
AGEP |
|
<= 0 |
no |
|
1 to 4 |
possible |
|
5 to 7 |
probable |
|
8 to 12 |
definite |
Specialty: Dermatology
