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Activity of 11-beta-Hydroxysteroid Dehydrogenase in a Patient with Cushing's Syndrome, Urine Cortisol and Ratio of Tetrahydrocortisol to Tetrahydrocortisone

Specialty:

Endocrinology, Nutrition & Dermatology
Clinical Laboratory

Objective:

ICD-10:

Description:

11-beta-hydroxysteroid dehydrogenase normally degrades cortisol to cortisone. In some patient's with Cushing's Syndrome there is a state of relative mineralocorticoid excess, which is associated with reduced activity of 11-beta-hydroxysteroid dehydrogenase.

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