The Acro-derma-ungual-lacrimal-tooth (ADULT) syndrome is one of the phenotypes associated with mutations in TP63.

Chromosome: 3q28

Gene: tumor protein 63 (TP63)


Inheritance: autosomal dominant


Clinical features:

(1) dry skin without erosions

(2) hair that is light-colored and fine

(3) sparse eyebrows and eyelashes

(4) nail dysplasia

(5) dental anomalies (conical teeth; small occlusal tables; hypodontia; defective enamel)

(6) decreased sweating with heat intolerance

(7) lacrimal duct atresia, which may be associated with chronic conjunctivitis and blepharitis

(8) breast and/or nipple hypoplasia

(9) excessive freckling in sun-exposed skin

(10) syndactyly of fingers and toes

(11) adermatoglyphia

(12) facial dysmorphism (elongated nose, thin kips, almond-shaped eyes)


Clinical findings may become more prominent with age.

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