A number of acquired conditions may be associated with nephrogenic diabetes insipidus (DI). Many of them affect the ability of the kidneys to maintain a hyperosmolar environment in the inner medulla of the kidney.


Renal disorders:

(1) chronic renal failure

(2) polycystic kidney disease

(3) medullary sponge kidney

(4) sickle cell disease

(5) diffuse renal infarcts

(6) infiltrative disease (amyloid, other)

(7) obstructive uropathy (bilateral urinary tract obstruction)

(8) pyelonephritis

(9) analgesic nephropathy

(10) uric acid nephropathy

(11) diabetic nephrosclerosis

(12) diuretic phase of acute tubular necrosis

(13) renal transplantation

(14) Sjogren's syndrome

(15) overdiuresis


Metabolic and nutritional disorders:

(1) hypokalemia and potassium depletion

(2) hypercalcemia with hypercalcuria

(3) hyperaldosteronism

(4) low protein diet

(5) polydipsia


Drug-related (13.17.07)


Some of the conditions are reversible, in which case reversal of the DI upon stopping the cause is diagnostic. For conditions that are irreversible it is necessary to exclude other causes.


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