The acquired-B phenomenon is a rare condition which can occur in several ways.
Features:
(1) The patient is type A1 and less often type O.
(2) There is anti-B in serum.
(3) The patient appears to acquire weak B antigen on the front type, which may only be detected with some antibodies.
(4) Reduction of the pH of a reacting anti-B reagent to pH 6 (acidification) results in a loss of reactivity.
Occurrence:
(1) cancer, usually gastrointestinal
(2) Gram-negative bacterial infection
(3) colon obstruction or enterocolitis
Mechanism:
(1) deacetylase activity converts A1 antigen to B-like substance
(2) in vitro absorption of B-antigen-like bacterial products in vitro onto A or O cells
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Specialty: Clinical Laboratory
