A number of factors may serve as absolute or relative contraindications for pancreas transplant. Many are shared with other major organ transplant procedures.
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Absolute Contraindications |
Relative Contraindications |
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body mass index > 35 kg per sq meter |
body mass index 30.1 to 35 kg per sq m |
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age < 18 years, or age > 65 years |
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recent retinal hemorrhage |
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symptomatic cerebrovascular disease |
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absence of appropriate social support network |
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hepatitis B disease with active viral replication and hepatic dysfunction |
hepatitis C disease with active viral replication and hepatic dysfunction |
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active infection |
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positive HIV serology |
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active, untreated peptic ulcer disease |
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ongoing substance abuse |
active smoking |
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major, ongoing and untreated psychiatric disorder |
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history of significant medical noncompliance |
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unable or unwilling to provide informed consent |
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insufficient cardiovascular reserve, uncorrectable coronary artery disease, recent myocardial infarction |
symptomatic peripheral vascular disease; untreatable aorto-iliac disease |
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significant, irreversible hepatic disease |
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significant, irreversible pulmonary disease |
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any systemic illness that would severely limit life expectancy or compromise recovery |
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positive lymphocytotoxic cross-match |
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history of malignancy treated within the past 2 years (exception: nonmelanoma skin carcinoma) |
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where:
• I would think the presence of metastatic cancer would serve as an absolute contraindication.
Specialty: Gastroenterology, Surgery, general
