Fleming et al identified factors associated with an impaired health-related quality of life in a patient coinfected with HIV and HCV (hepatitis C virus). These can help identify a patient who may benefit from interventions to improve life quality. The authors are from Boston University, Beth Israel Deaconess Hospital, Veterans Affairs Healthcare System and the Lahey Clinic.

Factors associated with impaired health-related quality of life:

(1) older age

(2) unemployed

(3) active injection drug use

(4) current or past depression



• Patients who were coinfected with HCV and HIV had a mean age of 46 years. Quantifying "older age" is a challenge. Being older than the mean is used in the implementation.


Additional factors:

(1) physical disability (Karnofsky score 10 to 80)

(2) White race

(3) not receiving highly active anti-retroviral therapy (HAART)


The presence of one or more risk factors can identify a patient who may benefit from interventions.

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