The American College of Rheumatology (ACR) and EULAR reported criteria for microscopic polyangiitis (MPA).
Parameters:
(1) p-ANCA or anti-myeloperoxidase-ANCA positivity
(2) c-ANCA or anti-proteinase3-ANCA positivity
(3) pauci-immune glomerulonephritis
(4) lung fibrosis or interstitial lung disease
(5) sino-nasal symptoms
(6) maximum absolute eosinophil count
Parameter |
Finding |
Points |
max absolute eosinophil count |
< 1 * 10^9/L |
0 |
|
>= 1 * 10^9/L |
-4 |
lung fibrosis or interstitial lung disease |
no |
0 |
|
yes |
3 |
sino-nasal symptoms |
no |
0 |
|
yes |
-3 |
c-ANCA or anti-proteinase3 ANCA |
no |
0 |
|
yes |
-1 |
pauci-immune glomerulonephritis |
no |
0 |
|
yes |
3 |
p-ANCA or anti-myeloperoxidase ANCA |
no |
0 |
|
yes |
6 |
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -8
• maximum score: 12
• A score >= 5 indicates MPA in a patient with a small/medium vessel vasculitis, with exclusion of vasculitis mimics.
Performance:
• The sensitivity was 91% and specificity 94%.
Specialty: Immunology/Rheumatology