Description

The American College of Rheumatology (ACR) and EULAR reported criteria for eosinophilic granulomatosis with polyangiitis (EGPA).


Parameters:

(1) maximum absolute eosinophil count

(2) obstructive airway disease

(3) nasal polyps

(4) c-ANCA or anti-proteinase3-ANCA positivity

(5) extravascular eosinophilic predominant inflammation

(6) mononeuritis multiplex/motor neuropathy not due to radiculopathy

(7) hematuria

 

Parameter

Finding

Points

max absolute eosinophil count

< 1 * 10^9/L

0

 

>= 1 * 10^9/L

5

obstructive airway disease

no

0

 

yes

3

nasal polyps

no

0

 

yes

3

c-ANCA or anti-proteinase3 ANCA

no

0

 

yes

-3

extravascular eosinophilic inflammation

no

0

 

yes

2

mononeuritis multiplex/motor neuropathy not radiculopathy

no

0

 

yes

1

hematuria

no

0

 

yes

-1

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: -4

• maximum score: 14

• A score >= 6 indicates EGPA in a patient with a small/medium vessel vasculitis, with exclusion of vasculitis mimics.


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