The American College of Rheumatology (ACR) and EULAR reported criteria for eosinophilic granulomatosis with polyangiitis (EGPA).
Parameters:
(1) maximum absolute eosinophil count
(2) obstructive airway disease
(3) nasal polyps
(4) c-ANCA or anti-proteinase3-ANCA positivity
(5) extravascular eosinophilic predominant inflammation
(6) mononeuritis multiplex/motor neuropathy not due to radiculopathy
(7) hematuria
Parameter |
Finding |
Points |
max absolute eosinophil count |
< 1 * 10^9/L |
0 |
|
>= 1 * 10^9/L |
5 |
obstructive airway disease |
no |
0 |
|
yes |
3 |
nasal polyps |
no |
0 |
|
yes |
3 |
c-ANCA or anti-proteinase3 ANCA |
no |
0 |
|
yes |
-3 |
extravascular eosinophilic inflammation |
no |
0 |
|
yes |
2 |
mononeuritis multiplex/motor neuropathy not radiculopathy |
no |
0 |
|
yes |
1 |
hematuria |
no |
0 |
|
yes |
-1 |
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -4
• maximum score: 14
• A score >= 6 indicates EGPA in a patient with a small/medium vessel vasculitis, with exclusion of vasculitis mimics.
Specialty: Immunology/Rheumatology