Patient selection: acute cholangitis
Grades: I (mild), II (moderate) or III (severe)
Criteria for Grade III - one or more of the following:
(1) hypotension requiring vasopressor support (dopamine >= 5 µg/kg/min or norepiphrine any dose; cardiovascular dysfunction)
(2) disturbance of consciousness (neurological dysfunction)
(3) PaO2/FIO2 ratio < 300 (respiratory dysfunction)
(4) oliguria or serum creatinine > 2.0 mg/dL (renal dysfunction)
(5) INR > 1.5 (hepatic dysfunction
(6) platelet count < 100,000 per µL (hematologic dysfunction)
Criteria for Grade II - 2 or more of the following:
(1) WBC count < 4,000 or > 12,000 per µL
(2) temperature >= 39°C
(3) >= 75 years of age
(4) serum total bilirubin >= 5 mg/dL
(5) hypoalbuminemia (less than 0.7 times the LLN)
Criteria for Grade I: not Grade II or III
