Dissemination in space in multiple sclerosis is identified by demonstration of multifocal CNS lesions on brain MRI.

Method of analysis: MRI


Dissemination in space is defined as >= 1 T2-hyperintense lesions in >= 2 of the following areas in the CNS:

(1) periventricular region of the brain

(2) cortical/juxtacortical region of the brain

(3) infratentorial region of the brain

(4) spinal cord


Gadolinium enhancement is not a required feature.

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