The TNM staging system is used by the American Joint Commission on Cancer (AJCC) and the Union Internationale Contre le Cancer (UICC).
Parameter |
Code |
Definition |
---|---|---|
primary tumor |
TX |
primary tumor cannot be assessed |
|
TX |
tumor proven by the presence of malignant cells in sputum or bronchial washings but not visualized by imaging or bronchoscopy |
|
T0 |
no evidence of primary tumor |
|
Tis |
carcinoma in situ |
|
T1 |
tumor <= 3 cm in diameter, surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus (not involving main bronchus) |
|
T1 |
superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus |
|
T2 |
more than 3 cm in diameter |
|
T2 |
involving the main bronchus, 2 cm or more distal to the carina |
|
T2 |
invading the visceral pleura |
|
T2 |
atelectasis or obstructive pneumonitis extending to the hilar region but not involving the entire lung |
|
T3 |
tumor of any size that directly invades the chest wall (including superior sulcus tumor), diaphragm, mediastinal pleura, parietal pericardium |
|
T3 |
tumor in the main bronchus less than 2 cm distal to the carina but without direct involvement of the carina |
|
T3 |
atelectasis or obstructive pneumonitis of the entire lung |
|
T4 |
tumor of any size invading the mediastinum, heart, great vessels, trachea, esophagus, vertebral body, or carina |
|
T4 |
tumor with a malignant pleural effusion |
regional lymph nodes |
NX |
regional lymph nodes cannot be assessed |
|
N0 |
no regional lymph node metastasis |
|
N1 |
metastasis to ipsilateral peribronchial and/or ipsilateral hilar lymph nodes, including direct extension |
|
N2 |
metastasis in ipsilateral mediastinal and/or subcarinal lymph nodes |
|
N3 |
metastasis in contralateral mediastinal, hilar, scalene or supraclavicular lymph nodes |
|
N3 |
metastasis to ipsilateral scalene or supraclavicular lymph nodes |
distant metastasis |
MX |
presence of distant metastasis cannot be assessed |
|
M0 |
no distant metastasis |
|
M1 |
distant metastasis (often liver, brain, bone, adrenal gland, kidney, and contralateral lung) |
|
M1 |
metastasis to nonregional lymph nodes, including jugular lymph nodes |
Regional lymph nodes
Intrapulmonic:
(1) hilar (proximal lobar)
(2) peribronchial
(3) intrapulmonic
Mediastinal:
(1) peritracheal and tracheobronchial
(2) pretracheal and retrotracheal, including precarinal
(3) aortic (includes subaortic, aorticopulmonary window, and periarotic)
(4) carinal
(5) periesophageal
(6) pulmonary ligament
(7) anterior mediastinal
(8) posterior mediastinal
Stages
Stage |
T |
N |
M |
---|---|---|---|
occult |
TX |
N0 |
M0 |
Stage 0 |
Tis |
N0 |
M0 |
Stage I |
T1 |
N0 |
M0 |
|
T2 |
N0 |
M0 |
Stage II |
T1 |
N1 |
M0 |
|
T2 |
N1 |
M0 |
Stage IIIA |
T1 |
N2 |
M0 |
|
T2 |
N2 |
M0 |
|
T3 |
N0 |
M0 |
|
T3 |
N1 |
M0 |
|
T3 |
N2 |
M0 |
Stage IIIB |
any T |
N3 |
M0 |
|
T4 |
any N |
M0 |
Stage IV |
any T |
any N |
M1 |
Specialty: Hematology Oncology, Surgery, general, Pulmonology