Therapy with 17-hydroxyprogesterone can prevent preterm labor in some women.

Drug: 17-alpha hydroxyprogesterone caproate



(1) singleton gestation

(2) history of previous spontaneous preterm birth

(3) 20 to 36 6/7 weeks


Therapy is to start at 16-20 weeks and continue until week 36 or delivery (whichever comes first).


Dose: 250 mg IM per week

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