Enteropathy-associated T-cell lymphoma (EATL) can be subclassified into 2 types based on a number of features. The prognosis for both types tends to be poor, especially if diagnosis is delayed.
Both show thickening of bowel wall in the affected segment.
Parameter
Type I ("classic", "secondary")
Type II ("primary")
association
celiac disease
sporadic, occasionally celiac disease
molecular findings
9q31.3 gain, 16q12.1 deletion
8q24 gain, 1q gain, 5q gain
presentation
refractory celiac disease
bowel perforation
histology
heterogeneous
monomorphic
positive phenotype
CD3, CD7
CD 56 (70%), CD8 (60%),
CD3, CD7
negative phenotype
CD56 (70%), CD8 (60%),
CD4 (90%)
CD4 )95%)
frequency
80-90%
10-20%
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