The precise cause of sclerosing mediastinitis is uncertain. It is believed to be associated with an abnormal immunological response to certain triggers.
Infectious causes:
(1) histoplasmosis
(2) aspergillosis
(3) cryptococcosis
(4) blastomycosis
(5) mucormycosis
(6) tuberculosis
Physical or chemical causes:
(1) radiation
(2) methysergide or other drugs
Other causes:
(1) familial
(2) sarcoidosis
(3) IgG4-related sclerosing disease (hyper-IgG4 disease)
(4) other autoimmune disease
(5) idiopathic
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Purpose: To identify possible triggers for sclerosing mediastinitis.
Specialty: Immunology/Rheumatology
Objective: clinical diagnosis, including family history for genetics
ICD-10: J98.5,
