Compilato et al proposed the Simple-Complex-Destroying (S-C-D) classification system for a patient with a long-standing oral ulcer. The authors are from the University of Palermo, II University of Naples, New York University and University of Foggia.
Patient selection: ulceration not healing withing 2 weeks, classified as simple
Differential diagnosis of a simple ulceration – benign:
(1) trauma
(2) necrotizing sialometaplasia
(3) eosinophilic ulcer
(4) Riga-Fede disease
(5) familial dysautonomia
(6) syphilis
(7) tuberculosis
(8) deep mycosis
(9) actinomycosis
Differential diagnosis of a simple ulceration – malignant:
(1) squamous cell carcinoma
(2) malignant salivary gland tumor
(3) Kaposi’s sarcoma
(4) hematologic malignancy
(5) malignant melanoma
(6) metastasis
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