RTOG/EORTC Criteria for Urinary Bladder Complications to Irradiation

Description

The Radiation Therapy Oncology Group (RTOG) and the European Organization for Research on the Treatment of Cancer (EORTC) provide criteria for assessing the complications of radiation therapy affecting the urinary bladder.

Guidelines:

(1) Change in affected parameter is ascribed to radiation therapy and not underlying or concurrent disease.

(2) Considered acute if occurs from day 1 to 90; after day 90 considered late complication.

Acute Complications

Grade 0: no change from baseline

Injury	Grade 1	Grade 2	Grade 3	Grade 4
frequency	frequency of urination or nocturia twice pretreatment habit	frequency of urination or nocturia that is less frequent than every hour	frequency with urgency and nocturia hourly or more frequently	NA
dysuria	dysuria or urgency not requiring medication	dysuria, urgency or bladder spasm requiring local anesthetic	dysuria, pelvic pain or bladder spasm requiring regular, frequent narcotic	NA
hematuria	NA	NA	gross with or without clot passage	requires transfusion
other	NA	NA	NA	acute bladder obstruction not secondary to clot passage, ulceration or necrosis

Grade 5: death directly due to radiation effect

Late Complications

Grade 0: no change from baseline

Injury	Grade 1	Grade 2	Grade 3	Grade 4
epithelial change	slight atropy	NA	NA	necrosis
telangiectasia	minor	generalized	severe and generalized, often with petechiae	NA
hematuria	microscopic	intermittent, macroscopic	frequent	severe hemorrhagic cystitis
frequency	NA	moderate	severe with dysuria
bladder capacity	NA	NA	reduction in bladder capacity (< 150 mL)	contracted bladder (< 100 mL)

Grade 5: death directly due to radiation late effect

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Description

Specialty

ICD-10