Huang et al identified risk factors associated with leukemic transformation in a patient with primary myelofibrosis. This can help identify patients who may benefit from more aggressive management. The authors are from the Mayo Clinic.
Parameters:
(1) platelet count at the time of diagnosis
(2) percent blasts in the peripheral blood at the time of diagnosis
Parameter |
Finding |
Points |
platelet count |
>= 100,000 per µL |
0 |
|
< 100,000 per µL |
1 |
percent blasts |
< 3% |
0 |
|
>= 3% |
1 |
number of risk factors =
= SUM(points for the 2 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 2
• The higher the number of risk factors the greater the risk for leukemic transformation.
Number of Risk Factors |
Percent with Leukemia at 5 Years |
0 |
15% |
1 or 2 |
58% (4 fold greater) |
Additional risk factors for a leukemia transformation:
(1) history of therapy with erythropoietin-stimulating agent
(2) history of therapy with danazol (an anabolic steroid with androgenic and antigonadotropic effects)
Specialty: Hematology Oncology
ICD-10: ,