Grover's Disease (transient acantholytic dermatosis, persistent or recurrent acantholytic dermatosis) may be associated with a number of risk factors. Some may be etiologic while others may cause an exacerbation.
Risk factors for Grover's disease:
(1) older age
(2) excessive sweating
(3) exposure to sun, heat and/or prolonged fever
(4) dry skin (xerosis)
(5) history of transplant (renal, bone marrow, heart)
(6) HIV infection
(7) other immunodeficiency or immunosuppression
(8) chronic renal failure
(9) chemotherapy
(10) malignancy (including leukemia)
(11) prolonged bedrest
(12) drug abuse
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