Queenan offered a method of assessing severity of hemolytic disease of the newborn based on amniotic fluid bilirubin.
Measurement on amniotic fluid: delta OD450
Upper Boundary Line for < 28 Weeks Gestation
y = 0.24
LOG10 [100 * (delta OD450)] = 0.24
Upper Boundary Line for 28 - 40 Weeks Gestation
week 28: y = 0.24
week 40: y = 0.133
slope = - 0.020
LOG10(100 * (delta OD450)) = ((-0.020) * (week gestation)) + 1.91
Lower Boundary Line
week 20: y = 0.126
week 40: y = 0.05
slope = -0.020
LOG10(100 * (delta OD450)) = ((- 0.020) * (week gestation)) + 1.5
Location
Interpretation
above upper boundary
intrauterine or neonatal death possible
within zone
area of overlap
below lower boundary
infant survives
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Specialty: Obstetrics & Gynecology, Clinical Laboratory