Arndt et al reported a prognostic score for a pediatric patient undergoing an allogeneic hematopoietic stem cell transplant. The authors are from Jena University in Germany.
Patient selection: pediatric patient
Parameters at the time of transplant or shortly before:
(1) reason for transplant
(2) serum ferritin in ng/mL
(3) serum cholinesterase (CHE) activity in microM•s
|
Parameter |
Finding |
Points |
|
reason for transplant |
aplastic anemia |
0 |
|
|
CML in chronic phase |
0 |
|
|
genetic disease |
0 |
|
|
leukemia or lymphoma in 1 or 2 remissions |
0 |
|
|
leukemia or lymphoma in > 2 remissions |
1 |
|
|
leukemia or lymphoma in relapse |
1 |
|
|
MDS, refractory cytopenia |
0 |
|
|
MDS, advanced |
1 |
|
|
myelofibrosis |
0 |
|
|
solid tumor |
1 |
|
serum ferritin |
<= 1,500 ng/mL |
0 |
|
|
> 1,500 ng/mL |
1 |
|
cholinesterase activity |
< 60 microM•s |
1 |
|
|
>= 60 microM•s |
0 |
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the greater the risk.
|
Total Score |
Risk |
5-Year Overall Survival |
|
0 |
low |
92% |
|
1 |
intermediate |
66% |
|
2 or 3 |
high |
17% |
Specialty: Clinical Laboratory, Hematology Oncology, Surgery, general
