Oudot et al evaluated children with acute lymphoblastic leukemia (ALL) who failed 3 or 4 drug induction therapy. They identified risk groups associated with response to salvage therapy. The authors are from multiple hospitals in France participating in the French Acute Lymphoblastic Leukemia Pediatric group (FRALLE) 93 protocol.
Parameters:
(1) type of ALL
(2) t(9;22) = Philadelphia chromosome, Ph+
(3) mediastinal mass
Type of ALL
t(9;22)
Mediastinal Mass
Risk Group
B-cell progenitor
absent
NA
low risk
T cell
NA
present
intermediate
B cell progenitor
present
NA
high risk
T cell
NA
absent
high risk
80% can achieve complete remission with salvage therapy.
40% of these will be long-term survivors.
The best option was matched sibling transplantation if a complete response can be achieved.
To read more or access our algorithms and calculators, please log in or register.
