Prognostic Factors of Knipp et al for a Patient More Than 60 Years of Age with Acute Myeloid Leukemia or Myelodysplasia

 

Patient selection: age > 60 years with MDS or AML

 

Factors associated with a worse prognosis:

(1) elevated serum LDH (> 400 IU/L)

(2) absence of Auer rods (Auer rods indicate some degree of maturation)

(3) high risk karyotype (>= 3 chromosomes abnormal and/or chromosome 7 affected)

(4) delay in therapy (time between diagnosis and induction therapy > 3 months)

 

The karyotype was the most important factor in determining outcome.

Karyotype	Complete Remission Rate	Median Survival
normal	70%	18 months
abnormal not high risk	69%	6 months
abnormal high risk	46%	4 months

 

A patient with an abnormal karyotype (high risk or not high risk) did not benefit from intensive chemotherapy.