Cervantes et al identified prognostic factors for younger patients with myelofibrosis and myeloid metaplasia. These can help identify a patient who may benefit from more aggressive management. The authors are from multiple hospitals in Spain, Italy, France and England.
NOTE: These findings are similar to those reported the previous year by Cervantes et al in a general population with myelofibrosis and myeloid metaplasia (see above).
Patient selection: primary myelofibrosis with age <= 55 years
Parameters:
(1) hemoglobin
(2) constitutional symptoms (fever, sweats for > 1 month, unintended weight loss > 10% from baseline)
(3) circulating blasts
Parameter
Finding
Points
hemoglobin
>= 10 g/dL
0
< 10 g/dL
1
constitutional symptoms
absent
0
present
1
circulating blasts
< 1%
0
>= 1%
1
prognostic score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the prognosis.
Prognostic Score
Risk Group
Median Survival
0 or 1
low
176 months
2 or 3
high
33 months
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